Wednesday, December 28, 2016

SHIKARI® S-ATA v2 ELISA kit for quantification of anti drug antibodies to ADALIMUMAB (HUMIRA®) with confirmation

Matriks Biotek® to introduce SHIKARI® S-ATA v2 ELISA kit to measure anti-adalimumab antibody levels and confirmation of the results in the same kit. 

Adalimumab (Humira®) is a fully humanized monoclonal antibody against TNF-α, and is approved for the treatment of RA and Crohn's disease (CD).  Even though it is fully humanized, adalimumab does not eliminate the risk of immunogenicity in both CD and RA patients.

Generation of antibodies-to-adalimumab (ATA) in the serum is associated with lower serum adalimumab concentrations and reduced response rate to treatment. 

 SHIKARI® Q-ADA v1 kit together with SHIKARI® S-ATA v2 ELISA kit can give definitive information about patient status when evaluated with different tests and clinical status of the patient. By knowing the trough level of the drug e.g. if it is below the Cmin of the drug and there is anti-drug antibodies then the course of treatment should be changed accordingly. Adalimumab dose can be escalated, other drugs can be added to treatment and end up with switching to another biological if necessary. By following patient’s adalimumab and anti-adalimumab drug (ATA) levels. Methotrexate or leflunomide prevents the development of neutralizing Abs against adalimumab so knowing and following up of anti-adalimumab drug levels will be highly valuable in the course of treatment. 

One of the major concern when detecting anti-adalimumab drug (ATA) levels is false positivity of the results. SHIKARI® S-ATA v2 ELISA kit can detect 30 ng/ml of ATA and to eliminate false positivity optimized Confirmation Regeant is added to the test system for convenience. 

You can find related and all 38 peer reviewed publications done by SHIKARI® ELISA kits at

For product insert please refer to

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