Thursday, January 19, 2017

SHIKARI® Q-RITUX and S-ATR ELISA Kits for quantitative measurement of rituximab and anti-rituximab antibodies


It is a medication used to treat certain autoimmune diseases and types of cancer. Specifically it is used for non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, idiopathic thrombocytopenic purpura, and pemphigus vulgaris.

Rituximab destroys both normal and malignant B cells that have CD20 on their surfaces and is therefore used to treat diseases which are characterized by having too many B cells, overactive B cells, or dysfunctional B cells.


ELISA kit for the measurement of rituximab in serum and plasma samples. The kit utilizes double monoclonal antibody technology for capturing and detection of the drug in a sandwich ELISA method with very high specifity. Kit is optimized for covering  Cmax and Cmin values of the drug  and suitable for trough level measurement. All reagents are ready to use and the test is very simple to perform. There is no cross reaction with any other proteins present in naïve human serum. In addition, there is no cross reaction with the other therapeutic immunoglobulins tested (infliximab (Remicade®), etanercept (Enbrel®), adalimumab (Humira®), bevacizumab (Avastin®) and trastuzumab (Herceptin®) )



It is the only ELISA kit on the market for the quantitative measurement of anti-rituximab antibodies in serum and plasma samples.  All reagents are ready to use and the test is very simple to perform. Kit allows to follow patients ADA levels along with trough levels of the drug and to make decision on dosage and and dosage intervals of the drug. Kit also includes optimized confirmation reagent to eliminate false positive reactions if any.

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